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Optimization of mobile phase composition for high-performance liquid chromatographic analysis of eleven priority substituted phenols

โœ Scribed by C.P. Ong; H.K. Lee; S.F.Y. Li

Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
316 KB
Volume
464
Category
Article
ISSN
1873-3778

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โœฆ Synopsis

Substituted phenols are of great environmental concern particularly as water pollutants'. Eleven phenols, listed by the United States Environmental Protection Agency (U.S.E.P.A.) as priority pollutants 2, have been subjected to many previous investigations3-lo. One of the more widely used techniques is high-performance liquid chromatography (HPLC) of which both reversed-phase isocratic and gradient elution analyses were reported. In this paper, the isocratic HPLC separation of these phenols is investigated. The separation of the eleven compounds is optimized by the use of the overlapping resolution mapping (ORM) scheme proposed by Glajch et aZ.ll. The aim of the optimization scheme is to predict the best mobile phase composition consisting of mixtures of water with various proportions of three common organic modifiers, methanol, acetonitrile and tetrahydrofuranr2.

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