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Optimization and Scale-Up of an Asymmetric Route to the LTB 4 Inhibitor Ontazolast

✍ Scribed by Roth, Gregory P.; Landi,, John J.; Salvagno, Annette M.; Müller-Bötticher, Hermann


Book ID
118124958
Publisher
American Chemical Society
Year
1997
Tongue
English
Weight
325 KB
Volume
1
Category
Article
ISSN
1083-6160

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ChemInform Abstract: Optimization and Sc
✍ G. P. ROTH; J. J. JUN. LANDI; A. M. SALVAGNO; H. MUELLER-BOETTICHER 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 39 KB 👁 1 views

Optimization and Scale-Up of an Asymmetric Route to the LTB 4 Inhibitor Ontazolast. -A potential industrial process involving a telescoped series of operations is described. Inexpensive chiral auxiliary α-pinene (I) is safely and effectively oxidized under phase transfer conditions to yield keto al