ChemInform Abstract: Optimization and Sc
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G. P. ROTH; J. J. JUN. LANDI; A. M. SALVAGNO; H. MUELLER-BOETTICHER
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Article
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2010
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John Wiley and Sons
⚖ 39 KB
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Optimization and Scale-Up of an Asymmetric Route to the LTB 4 Inhibitor Ontazolast. -A potential industrial process involving a telescoped series of operations is described. Inexpensive chiral auxiliary α-pinene (I) is safely and effectively oxidized under phase transfer conditions to yield keto al