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Development and Scale-Up of an Optimized Route to the Peptide Boronic Acid, CEP-18770

✍ Scribed by Roemmele, Renee C.; Christie, Michael A.


Book ID
119963360
Publisher
American Chemical Society
Year
2013
Tongue
English
Weight
658 KB
Volume
17
Category
Article
ISSN
1083-6160

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ChemInform Abstract: Optimization and Sc
✍ G. P. ROTH; J. J. JUN. LANDI; A. M. SALVAGNO; H. MUELLER-BOETTICHER πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 39 KB πŸ‘ 1 views

Optimization and Scale-Up of an Asymmetric Route to the LTB 4 Inhibitor Ontazolast. -A potential industrial process involving a telescoped series of operations is described. Inexpensive chiral auxiliary Ξ±-pinene (I) is safely and effectively oxidized under phase transfer conditions to yield keto al