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Development and Scale-Up of an Optimized Route to the ALK Inhibitor CEP-28122

✍ Scribed by Allwein, Shawn P.; Roemmele, Renee C.; Haley, James J.; Mowrey, Dale R.; Petrillo, Daniel E.; Reif, James J.; Gingrich, Diane E.; Bakale, Roger P.


Book ID
119958280
Publisher
American Chemical Society
Year
2012
Tongue
English
Weight
503 KB
Volume
16
Category
Article
ISSN
1083-6160

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ChemInform Abstract: Optimization and Sc
✍ G. P. ROTH; J. J. JUN. LANDI; A. M. SALVAGNO; H. MUELLER-BOETTICHER πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons βš– 39 KB πŸ‘ 1 views

Optimization and Scale-Up of an Asymmetric Route to the LTB 4 Inhibitor Ontazolast. -A potential industrial process involving a telescoped series of operations is described. Inexpensive chiral auxiliary Ξ±-pinene (I) is safely and effectively oxidized under phase transfer conditions to yield keto al