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Optimal two-stage designs for phase ii clinical trials with differentiation of complete and partial responses

✍ Scribed by Lin, Shang P.; Chen, T. Timothy


Book ID
127159562
Publisher
Taylor and Francis Group
Year
2000
Tongue
English
Weight
758 KB
Volume
29
Category
Article
ISSN
0361-0926

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Optimal three-stage designs for phase II
✍ T. Timothy Chen πŸ“‚ Article πŸ“… 1997 πŸ› John Wiley and Sons 🌐 English βš– 136 KB πŸ‘ 2 views

The objective of a phase II cancer clinical trial is to screen a treatment that can produce a similar or better response rate compared to the current treatment results. This screening is usually carried out in two stages as proposed by Simon. For ineffective treatment, the trial should terminate at