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Optimal dose of Gd-DTPA in dynamic MR studies

✍ Scribed by Henry Rusinek; Vivian S. Lee; Glyn Johnson

Publisher
John Wiley and Sons
Year
2001
Tongue
English
Weight
169 KB
Volume
46
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

The relationship between the administered dose d of Gd‐DTPA and the accuracy of measurements of the glomerular filtration rate G and the cardiac output O was investigated. For a wide range of values the concentration of Gd‐DTPA can be uniquely derived from MR signals and precontrast longitudinal relaxation time. Fixed and random errors in these measured variables were analyzed. Depending on noise level and the level of renal function, errors in G reach a minimum for d = 1.4–2.8 mmol. Random errors in G are relatively insensitive to d as long as d > 1.5 mmol. These results establish the feasibility of dynamic MR measurements using doses of Gd‐DTPA that are several times lower than current standards. Magn Reson Med 46:312–316, 2001. © 2001 Wiley‐Liss, Inc.

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