Optimal control of the chemotherapy of HIV
โ Scribed by Denise Kirschner; Suzanne Lenhart; Steve Serbin
- Book ID
- 105998931
- Publisher
- Springer
- Year
- 1997
- Tongue
- English
- Weight
- 563 KB
- Volume
- 35
- Category
- Article
- ISSN
- 0303-6812
No coin nor oath required. For personal study only.
๐ SIMILAR VOLUMES
Analytical gradients of all constraints are constructed and the problem solved numerically. The optimal treatment is low intensity therapy followed by high intensity therapy.
## Abstract A system of ordinary differential equations, which describes the interaction of HIV and __T__โcells in the immune system is utilized, and optimal controls representing drug treatment strategies of this model are explored. Two types of treatments are used, and existence and uniqueness re
In the paper, it has been proved that some optimal control problems resulting from the simplest models of cancer chemotherapy lead to singular control solutions. The singularity seems to be a characteristic feature of bilinear models even if dynamics of the drug activity or reaction of critical norm