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Optically Active Total Synthesis of Calphostin D

โœ Scribed by Hauser, Frank M.; Sengupta, Dipanjan; Corlett, Stephen A.


Book ID
127252397
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
321 KB
Volume
59
Category
Article
ISSN
0022-3263

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The total synthesis of optically active clianochvine-I, an ergot alkaloid, was accomplished using palladium-catalyzed intramoleeular cyclization (Heck reaction) as a key step. The conjugate ester (6) was obtained in 2 steps from optically active 4-bmmotryptophan (10), and the cyclization of 6 procee