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Total synthesis of optically active chanoclavine-I

โœ Scribed by Yuusaku Yokoyama; Kazuhiro Kondo; Masako Mitsuhashi; Yasuoki Murakami

Book ID
104258730
Publisher
Elsevier Science
Year
1996
Tongue
French
Weight
221 KB
Volume
37
Category
Article
ISSN
0040-4039

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โœฆ Synopsis

The total synthesis of optically active clianochvine-I, an ergot alkaloid, was accomplished using palladium-catalyzed intramoleeular cyclization (Heck reaction) as a key step. The conjugate ester (6) was obtained in 2 steps from optically active 4-bmmotryptophan (10), and the cyclization of 6 proceeded smoothly without racemization to give the key intermediate, trieyelie tetrahydrobenz [c,d]indole derivative (7), in high yield.

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