Opinion: Telomeres in T and B cells
β Scribed by Hodes, Richard J.; Hathcock, Karen S.; Weng, Nan-ping
- Book ID
- 109957773
- Publisher
- Nature Publishing Group
- Year
- 2002
- Tongue
- English
- Weight
- 497 KB
- Volume
- 2
- Category
- Article
- ISSN
- 1474-1741
- DOI
- 10.1038/nri890
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## Abstract The telomeric checkpoint is emerging as a critical sensor of cellular damage, playing a major role in human aging and cancer development. In the meantime, telomere biology is rapidly evolving from a basic discipline to a translational branch, capable of providing major hints for biomark
About 20% of leukemic bone marrow cells from each of two patients with B-cell lymphoid leukemias showed apparent translocations which appeared to be the result of telomeric association. In one patient, whole chromosomes were associated telomere to telomere in pairs; in the other patient, telomeres o