✦ LIBER ✦

Telomeric association of chromosomes in B-cell lymphoid leukemia

✍ Scribed by Peter H. Fitzgerald; Christine M. Morris

Book ID: 104707328
Publisher: Springer
Year: 1984
Tongue: English
Weight: 801 KB
Volume: 67
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00291396

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✦ Synopsis

About 20% of leukemic bone marrow cells from each of two patients with B-cell lymphoid leukemias showed apparent translocations which appeared to be the result of telomeric association. In one patient, whole chromosomes were associated telomere to telomere in pairs; in the other patient, telomeres of whole chromosomes were associated with breakpoints located close to the proximal or distal ends of the heterochromatic band 1q12. Repeated base sequences, particularly (CA)n sequences, are believed to be the basis of telomere pairing, and likewise repeated base sequences of heterochromatin may explain the association of 1qh and telomeres. Telomeric association may be considered as a potential origin of new stable cytogenetic combinations that have a role in oncogene transposition and tumor etiology.

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