The lipophilic, chiral, C h -methylated h-amino acid L-(h Me)Aoc (2-methyl-2-amino-octanoic acid) was prepared using a chemo-enzymatic approach. Two series of terminally protected model peptides, from dimer through to hexamer, containing L-(h Me)Aoc in combination with either Gly or Aib, were synthe
✦ LIBER ✦
Onset of the fully extended conformation in (αMe)Leu derivatives and short peptides
✍ Scribed by C. Toniolo; M. Pantano; F. Formaggio; M. Crisma; G.M. Bonora; A. Aubry; D. Bayeul; A. Dautant; W.H.J. Boesten; H.E. Schoemaker; J. Kamphuis
- Book ID
- 116091515
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 760 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0141-8130
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The dehydro-residue containing peptides N-Ac-dehydro-Phe-L-Leu-OCH3 ( I ) and N-Acdehydro-Phe-NorVal-OCH, (11) were synthesized by the usual workup procedures. The peptides crystallize from their solutions in methanol in space group P6,: ( I ) a = b = 12.528(2) A, c = 21.653(5) A; (11) a = b = 12.53