Online Microreactors/Capillary Electrophoresis/Mass Spectrometry for the Analysis of Proteins and Peptides
β Scribed by Licklider, Larry.; Kuhr, Werner G.; Lacey, Martin P.; Keough, Thomas.; Purdon, Michael P.; Takigiku, Ray.
- Book ID
- 126944031
- Publisher
- American Chemical Society
- Year
- 1995
- Tongue
- English
- Weight
- 847 KB
- Volume
- 67
- Category
- Article
- ISSN
- 0003-2700
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Capillary zone electrophoresis (CZE) coupled with an on-line mass spectrometric (MS) detection system by an atmospheric pressure electrospray ionization (ESI) interface has been used successfully for separations of peptide and protein mixtures. For CZE-MS, ESI produces multiply charged molecular ion
## Abstract In the present work, an exhaustive review of the main developments and applications of CEβMS for peptide analysis is given. This review includes the use of different CE separation modes, MS analyzers, capillary coatings, preconcentration techniques, onβchip applications as well as other