𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Online coupling of enantioselective capillary gas chromatography with proton nuclear magnetic resonance spectroscopy

✍ Scribed by Maximilian Kühnle; Diana Kreidler; Karsten Holtin; Harri Czesla; Paul Schuler; Volker Schurig; Klaus Albert

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
149 KB
Volume
22
Category
Article
ISSN
0899-0042

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

The hyphenation of enantioselective capillary gas chromatography and mass spectrometry is not always sufficient to distinguish between structural isomers, thus requiring peak identification by NMR spectroscopy. Here the first online coupling of enantioselective capillary gas chromatography with proton nuclear resonance spectroscopy is described for the unfunctionalized chiral alkane 2,4‐dimethylhexane resolved on octakis(6‐O‐methyl‐2,3‐di‐O‐pentyl)‐γ‐cyclodextrin at 60°C. NMR allows constitutional and configurational isomers (diastereomers and enantiomers) to be distinguished. Enantiomers display identical spectra at different retention times, which enable an indirect identification of these unfunctionalized alkanes. The presented method is still at an early development stage, and will require instrumental optimization in the future. Chirality 2010. © 2010 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Coupling of chromatography and NMR. 3—st
Coupling of chromatography and NMR. 3—study of flowing gas chromatographic fractions by proton magnetic resonance
✍ Joachim Buddrus; Helmut Herzog 📂 Article 📅 1981 🏛 John Wiley and Sons 🌐 English ⚖ 245 KB

## Abstract A procedure is described which allows the recording of ^1^H NMR spectra from gas chromatographic (GC) fractions flowing through the magnetic field with a velocity of __c__. 0.6 cm/s. The spectra are obtained by the pulse Fourier transform technique; the beginning and the termination of

Proton nuclear magnetic resonance spectr
Proton nuclear magnetic resonance spectroscopy studies of the inclusion complex of piroxicam with β-cyclodextrin
✍ G. Fronza; A. Mele; E. Redenti; P. Ventura 📂 Article 📅 1992 🏛 John Wiley and Sons 🌐 English ⚖ 326 KB 👁 1 views

Proton nuclear magnetic resonance spectroscopy showed that piroxicam sodium salt forms an inclusion complex with beta-cyclodextrin in aqueous solution. The 1:1 stoichiometry of the complex was determined by the continuous variation method. Significant nuclear Overhauser effects were observed between

Effect of J-coupling on lipid compositio
Effect of J-coupling on lipid composition determination with localized proton magnetic resonance spectroscopy at 9.4 T
✍ Atiyah Yahya; Anthony G. Tessier; B. Gino Fallone 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 281 KB 👁 1 views

## Abstract ## Purpose: To demonstrate, at 9.4 T, that J‐coupling interactions exhibited by lipid protons affects lipid composition determination with a point resolved spectroscopy (PRESS) sequence. ## Materials and Methods: Experiments were conducted on four oils (almond, corn, sesame, and sunf