Proton nuclear magnetic resonance spectroscopy studies of the inclusion complex of piroxicam with β-cyclodextrin

✍ Scribed by G. Fronza; A. Mele; E. Redenti; P. Ventura

• Publisher: John Wiley and Sons
• Year: 1992
• Tongue: English
• Weight: 326 KB
• Volume: 81
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600811206

✦ Synopsis

Proton nuclear magnetic resonance spectroscopy showed that piroxicam sodium salt forms an inclusion complex with beta-cyclodextrin in aqueous solution. The 1:1 stoichiometry of the complex was determined by the continuous variation method. Significant nuclear Overhauser effects were observed between the inner protons of beta-cyclodextrin and protons of both the aromatic rings of piroxicam sodium salt, a result indicating that two isomeric 1:1 complexes must be present in solution within the range of concentrations investigated. The overall association constant was 113 M at 298 K. At concentrations less than 1.0 x 10(-3) M, the complex is completely dissociated.