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One-pot synthesis of pharmacologically active secondary and tertiary 1-(3,3-diarylpropyl)amines via rhodium-catalysed hydroaminomethylation of 1,1-diarylethenes

โœ Scribed by Thorsten Rische; Peter Eilbracht


Book ID
108379211
Publisher
Elsevier Science
Year
1999
Tongue
French
Weight
299 KB
Volume
55
Category
Article
ISSN
0040-4020

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Selective one-pot synthesis of secondary
โœ Thorsten Rische; Peter Eilbracht ๐Ÿ“‚ Article ๐Ÿ“… 1998 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 521 KB

Secondary and tertiary amines are selectively prepared in high yields by a one-pot reduction / multiple alkylation procedure from aromatic nitro compounds with styrenes, cyclic olefins or heterofunctionalised olefins, carbon monoxide and hydrogen in the presence of [Rh(cod)CIL as catalyst.