One-Pot Synthesis of 2-Pyridones via Chemo- and Regioselective Tandem Blaise Reaction of Nitriles with Propiolates
✍ Scribed by Chun, Yu Sung; Ryu, Ka Yeon; Ko, Young Ok; Hong, Joo Yeon; Hong, Jongki; Shin, Hyunik; Lee, Sang-gi
- Book ID
- 111950476
- Publisher
- American Chemical Society
- Year
- 2009
- Tongue
- English
- Weight
- 771 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0022-3263
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A novel tandem one-pot method for the synthesis of a-aminomethylene-c-butyrolactone derivatives has been developed through the regioselective epoxide opening reactions with the Blaise reaction intermediates, generated by the reaction of a Reformatsky reagent with nitriles. Formation of a modified Bl
## Abstract The reaction of the Reformatsky reagent derived from ethyl bromoacetate and subsequent coupling of the resulting Blaise intermediate with oxiranes allows the synthesis of the title compounds in fair yields.