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One-pot synthesis of [11C]ureas via triphenylphosphinimines

✍ Scribed by Erica W. van Tilburg; Albert D. Windhorst; Margreet van der Mey; Jacobus D. M. Herscheid

Publisher
John Wiley and Sons
Year
2006
Tongue
French
Weight
148 KB
Volume
49
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

A series of ^11^C‐labeled ureas was prepared using a rapid and efficient one‐pot procedure. First, the intermediate [^11^C]phenylisocyanate was formed with phenyltriphenylphosphinimine and [^11^C]CO~2~. A range of amines was then reacted with the [^11^C]phenylisocyanate yielding the [^11^C]urea derivatives in short synthesis times. This easy‐to‐handle method circumvents disadvantages of known procedures and generates the possibility to prepare other kinds of ^11^C‐labeled compounds using a variety of phenylphosphinimines in combination with different nucleophiles. The presented approach is an alternative to the use of established methods in ^11^C‐labeling chemistry. Copyright © 2006 John Wiley & Sons, Ltd.

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