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One-Pot, Direct Incorporation of [11C]CO2 into Carbamates

✍ Scribed by Jacob M. Hooker; Achim T. Reibel; Sidney M. Hill; Michael J. Schueller; Joanna S. Fowler

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
323 KB
Volume
48
Category
Article
ISSN
0044-8249

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✦ Synopsis

Abstract

Why beat about the bush? An operationally simple and mild reaction based on the direct fixation of ^11^CO~2~ with 1,8‐diazabicyclo[5.4.0]undec‐7‐ene (DBU) has been developed for the synthesis of ^11^C‐labeled carbamates at 75 °C within 10 minutes in radiochemical yields above 70 % (see scheme). This strategy should be immediately useful for the construction of new radiotracers for positron emission tomography and other applications.magnified image

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