One-pot regioselective synthesis of tetrahydroindazolones and evaluation of their antiproliferative and Src kinase inhibitory activities
β Scribed by V. Kameshwara Rao; Bhupender S. Chhikara; Rakesh Tiwari; Amir Nasrolahi Shirazi; Keykavous Parang; Anil Kumar
- Book ID
- 113496345
- Publisher
- Elsevier Science
- Year
- 2012
- Tongue
- English
- Weight
- 713 KB
- Volume
- 22
- Category
- Article
- ISSN
- 0960-894X
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Two classes of 1,4-disubstituted 1,2,3-triazoles were synthesized using one-pot reaction of Ξ±-tosyloxy ketones/Ξ±-halo ketones, sodium azide, and terminal alkynes in the presence of aq PEG (1:1, v/v) using the click chemistry approach and evaluated for Src kinase inhibitory activity. Structure-activi