4-Aryl-4H-naphthopyrans derivatives: one-pot synthesis, evaluation of Src kinase inhibitory and anti-proliferative activities
✍ Scribed by Ali Rafinejad, Asal Fallah-Tafti, Rakesh Tiwari…
- Book ID
- 120802299
- Publisher
- Springer (Biomed Central Ltd.)
- Year
- 2012
- Tongue
- English
- Weight
- 267 KB
- Volume
- 20
- Category
- Article
- ISSN
- 1560-8115
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## Abstract An ecofriendly and economical method for the synthesis of 3‐substituted indoles (IV) (18 examples) via one‐pot three‐component coupling reaction of various benzaldehydes, N‐methylaniline, and indoles using Yb(OTf)~3~‐SiO~2~ as catalyst is presented.
Two classes of 1,4-disubstituted 1,2,3-triazoles were synthesized using one-pot reaction of α-tosyloxy ketones/α-halo ketones, sodium azide, and terminal alkynes in the presence of aq PEG (1:1, v/v) using the click chemistry approach and evaluated for Src kinase inhibitory activity. Structure-activi