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One-pot concise syntheses of benzimidazo[2,1-a]isoquinolines by a microwave-accelerated tandem process

✍ Scribed by Noriko Okamoto; Keisuke Sakurai; Minoru Ishikura; Kei Takeda; Reiko Yanada

Book ID: 104096587
Publisher: Elsevier Science
Year: 2009
Tongue: French
Weight: 514 KB
Volume: 50
Category: Article
ISSN: 0040-4039
DOI: 10.1016/j.tetlet.2009.04.126

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✦ Synopsis

Direct, efficient syntheses of the benzimidazo[2,1-a]isoquinoline ring system have been achieved with 2bromoarylaldehydes, terminal alkynes, and 1,2-phenylenediamines by a microwave-accelerated tandem process in which a Sonogashira coupling, 5-endo cyclization, oxidative aromatization, and 6-endo cyclization can be performed in a single synthetic operation.

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