Oncolytic adenoviral vector carrying the cytosine deaminase gene for melanoma gene therapy
β Scribed by Liu, Y; Deisseroth, A
- Book ID
- 110019362
- Publisher
- Nature Publishing Group
- Year
- 2006
- Tongue
- English
- Weight
- 301 KB
- Volume
- 13
- Category
- Article
- ISSN
- 0929-1903
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## Abstract ## Background Cytosine deaminase (CD) activates prodrug 5βFC to 5βFU and is used for suicide gene therapy (the CD/5βFC system). __E. coli__ uracil phosphoribosyltransferase (UPRT) is a pyrimidine salvage enzyme that directly converts 5βFU into 5βfluorouridine monophosphate and improves
The bacterial enzyme cytosine deaminase (CD) catalyzes the conversion of 5-fluorocytosine (5-FC) to the lethal 5-fluorouracil (5-Fu) and so provides a useful system for selective killing of gene-modified mammalian tumor cells. Cloning of the CD gene from Escherichiu coli and expression in human tumo