The use of adenoviral vectors for gene therapy and gene transfer in vivo
β Scribed by Jonathan L Bramson; Frank L Graham; Jack Gauldie
- Publisher
- Elsevier Science
- Year
- 1995
- Tongue
- English
- Weight
- 584 KB
- Volume
- 6
- Category
- Article
- ISSN
- 0958-1669
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π SIMILAR VOLUMES
Crigler-Najjar type 1 disease (CN1) is a rare inherited metabolic disease characterized by complete absence of hepatic UDP-glucuronosyl transferase (UGT1), resulting in high levels of unconjugated bilirubin. CN1 is an attractive candidate disease for gene therapy. Here we show that in vivo neonatal
## Abstract ## Background Because gene therapy of the future will primarily take an __in vivo__ approach, a number of problems associated with its current implementation exist. Currently, repeated delivery of a vector __in vivo__ is necessary to ensure adequate transfer of the therapeutic gene. Th