Gene therapy of hepatocellular carcinoma in vitro and in vivo in nude mice by adenoviral transfer of the escherichia coli purine nucleoside phosphorylase gene

Acquired immunity in nude mice induced b

Acquired immunity in nude mice induced by expression of the IL-2 or IL-4 gene in human pancreatic carcinoma cells and anti-tumor effect generated by In vivo gene transfer using retrovirus

✍ Masaki Kimura; Yu Yoshida; Mitsuro Narita; Keizo Takenaga; Toshinao Takenouchi; 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 French ⚖ 330 KB 👁 2 views

We have examined the anti-tumor effect in nude mice caused by human pancreatic cancer cells (AsPC-1) modified to secrete IL-2 or IL-4. Loss of tumorigenicity of cytokineproducing, but not wild-type, cells was observed despite their unaltered in vitro proliferation rates; and these anti-tumor effects