Development of a hypoxia-inducible cytosine deaminase expression vector for gene-directed prodrug cancer therapy

Gene-directed enzyme prodrug therapy for

Gene-directed enzyme prodrug therapy for prostate cancer in a mouse model that imitates the development of human disease

✍ Rosetta Martiniello-Wilks; Allison Dane; Dale J. Voeks; Geetha Jeyakumar; Elin M 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 310 KB 👁 1 views

## Abstract ## Background Gene‐directed enzyme prodrug therapy (GDEPT) based on the __E. coli__ enzyme purine nucleoside phosphorylase (PNP) represents a new approach for treating slow growing tumours like prostate cancer (PCa). Expressed enzyme converts a systemically administered prodrug, fludar