## Abstract Somatic mutations of the __PIK3CA__ gene have recently been detected in various human cancers, including sporadic colorectal cancer. However, mutations of the __PIK3CA__ gene in hereditary colorectal cancers have not been clarified. To elucidate the mutation status in familial adenomato
Oncogenic PIK3CA mutations in colorectal cancers and polyps
β Scribed by Vicki L.J. Whitehall; Celestine Rickman; Catherine E. Bond; Ingunn Ramsnes; Sonia A. Greco; Aarti Umapathy; Diane McKeone; Rebecca J. Faleiro; Ron L. Buttenshaw; Daniel L. Worthley; Sam Nayler; Zhen Zhen Zhao; Grant W. Montgomery; Kylie-Ann Mallitt; Jeremy R. Jass; Nagahide Matsubara; Kenji Notohara; Tatsuhiro Ishii; Barbara A. Leggett
- Book ID
- 112101605
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- French
- Weight
- 279 KB
- Volume
- 131
- Category
- Article
- ISSN
- 0020-7136
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract The PI3KβAKT pathway is activated in a variety of human cancers, resulting in disturbance of cell growth, proliferation and survival. Among the factors affecting the pathway, the __KβRas__ mutation and __PIK3CA__ mutation are the most common oncogenic alterations in colorectal cancer. W