Oncogene amplification: the role of Myc overexpression in tumorigenesis
✍ Scribed by Kari Alitalo; Tomi P. Mäkelä; Päivi J. Koskinen; Imre Västrik
- Book ID
- 112292937
- Publisher
- Springer
- Year
- 1992
- Tongue
- English
- Weight
- 109 KB
- Volume
- 343
- Category
- Article
- ISSN
- 1618-2650
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Amplification without structural rearrangements of the c-myc proto-oncogene was found in 14 of 44 primary cervical neoplasms. There was no apparent correlation with stage of disease or degree of cellular differentiation. The prognostic significance of c-myc amplification cannot be determined from th
c-myc oncogene is the most extensively studied member of the myc gene family, which now consists of three characterized members, namely the c-myc, N-myc, and L-myc genes. Deregulation owing to amplification and/or rearrangements of the c-myc gene have been described in a variety of human malignancie