N-myc ONCOGENE AMPLIFICATION IN RHABDOMYOSARCOMA AT RELEASE
β Scribed by Garson, J.A.; Clayton, J.; Mcintyre, P.; Kemshead, J.T.
- Book ID
- 122982892
- Publisher
- The Lancet
- Year
- 1986
- Tongue
- English
- Weight
- 261 KB
- Volume
- 327
- Category
- Article
- ISSN
- 0140-6736
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A parent rhabdomyosarcoma cell line designated SCMC-RM2 was established from bone-marrow tumor cells taken from an I I-year-old girl with an embryonal rhabdomyosarcoma. Subsequently a cloned SCMC-RM2-I cell line was isolated from a parent line. These cell lines grew as adherent monolayers in liquid
c-myc oncogene is the most extensively studied member of the myc gene family, which now consists of three characterized members, namely the c-myc, N-myc, and L-myc genes. Deregulation owing to amplification and/or rearrangements of the c-myc gene have been described in a variety of human malignancie