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On triazoles XLIV [1]. synthesis of new ring systems containing imidazo[2′,1′:3,4] [1,2,4] triazolo [1,5-a]pyrimidine and imidazo[1′,2′:2,3][1,2,4]triazolo[1,5-a]pyrimidine skeleton

✍ Scribed by Gábor Berecz; József Reiter; Gyula Argay; Alajos Kálmán

Publisher
Journal of Heterocyclic Chemistry
Year
2002
Tongue
English
Weight
85 KB
Volume
39
Category
Article
ISSN
0022-152X

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✦ Synopsis

Abstract

Dedicated to Dr. János Császár on the occasion of his 70^th^ birthday

Ring transformation of 2‐cyanoimido‐3‐methyl‐1,3‐oxazolidine (10) yielded 5‐amino‐3‐[N‐(2‐hydrox‐yethyl)‐N‐methyl]amino‐1__H__‐1,2,4‐triazole (6) that was ring closed with different β‐keto esters to 2‐[N‐(2‐hydroxyethyl)‐N‐methyl]amino‐1,2,4‐triazolo[1,5‐a]pyrimidinones (4). Cyclisation of derivatives 4 led to imidazo[2′,1′:3,4][1,2,4]triazolo[1,5‐a]pyrimidines (2) and imidazo[1′,2′:2,3][1,2,4]triazolo[1,5‐a]pyrim‐idines (3) representing 10 novel ring systems. Besides spectroscopical evidence of structure of derivatives 2 and 3 X‐ray diffraction analysis of derivative 2b was also performed.

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