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On the synthesis of platelet-activating factor via acetylation of 1-alkyl-sn-glycero-3-phosphocholine. Formation of structural isomer of PAF in the presence of bases

✍ Scribed by V.V Chupin; O.V Ostapenko; V.N Klykov; M.V Anikin; G.A Serebrennikova

Publisher: Elsevier Science
Year: 1996
Tongue: English
Weight: 537 KB
Volume: 81
Category: Article
ISSN: 0009-3084
DOI: 10.1016/0009-3084(96)02530-3

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✦ Synopsis

It has been shown that platelet-activating factor (PAF) specimens prepared via acetylation of 1-alkyl-sn-glycero-3-phosphocholine (lyso-PF) with acetic anhydride are heterogeneous. The contaminated compound was isolated and identified to be the structural isomer of PAF, 1-alkyl-3-acetyl-sn-glycero-2-phosphocholine (iso-PAF). It appeared, that iso-PAF is formed when performing the reaction in the presence of organic bases,but not under acid catalysis. The mechanism of iso-PAF formation is discussed.

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