Unsaturated platelet-activating factor (PAF) aggregates thrombocytes of healthy female volunteers and releases within 1 rain up to 30.95% of the platelet serotonin. Indomethacin does not inhibit the aggregation but reduces the release of serotonin induced by unsaturated PAF in citrated platelet-rich
A facile method for the preparation of 1-O-alkyl-2-O-acetoyl-sn-glycero-3-phosphocholines (platelet activating factor)
β Scribed by Toshio Muramatsu; Nagao Totani; Helmut K. Mangold
- Publisher
- Elsevier Science
- Year
- 1981
- Tongue
- English
- Weight
- 343 KB
- Volume
- 29
- Category
- Article
- ISSN
- 0009-3084
No coin nor oath required. For personal study only.
β¦ Synopsis
Biologically active l-O-alkyl-2-O-acetoyl-sn-glycero-3-phosphocholines are prepared in good yields from raffish (Hydrolagus colliei) liver oil, an inexpensive natural product, that contains over 70% neutral ether lipids.
π SIMILAR VOLUMES
A specific acetylhydrolase that inactivates platelet activating factor (PAF; 1alkyl-2-acetyl-sn-glycero-3-phosphocholine), a potent cellular mediator in mammalian cells, by removal of the sn-2 acetyl moiety, has been found in the cytosolic fraction of several postemhryonir developmental stages and s
In a study designed to explore the physical chemical characteristics of platelet activating factor (PAF), or 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine, the critical miceUar concentration of this compound, as well as the propionyl, butyryl and hexanoyl homologs was determined. In addition, an an
Pretreatment of macrophages with 12-0-tetradecanoylphorbol-13-acetate (TPA) has been shown to enhance the release of arachidonic acid from cell phospholipids in response to agonist stimulation. This study describes the ability of TPA to also alter calcium ionophore A23 187-induced incorporation of [
wide range of biological activities which are relevant A sensitive method for determining platelet-activatin the development of inflammation and endotoxic ing factor acetylhydrolase (PAF-AH) activity in human shock (4, 12). PAF acts via a specific receptor that is serum, using high-performance liqui