✦ LIBER ✦

Unsaturated 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholines (unsaturated platelet-activating factor): aggregation of human platelets after incubation with indomethacin, creatinephosphate/creatinephosphokinase, xylocain and hirudine, and serotonin release after incubation with indomethacin

✍ Scribed by R. Korth; H.K. Mangold; T. Muramatsu; N. Zöllner

Publisher: Elsevier Science
Year: 1985
Tongue: English
Weight: 220 KB
Volume: 36
Category: Article
ISSN: 0009-3084
DOI: 10.1016/0009-3084(85)90002-7

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✦ Synopsis

Unsaturated platelet-activating factor (PAF) aggregates thrombocytes of healthy female volunteers and releases within 1 rain up to 30.95% of the platelet serotonin. Indomethacin does not inhibit the aggregation but reduces the release of serotonin induced by unsaturated PAF in citrated platelet-rich plasma (PRP). Creatinephosphate combined with creatinephosphokinase (CP/CPK) inhibits the second phase, whereas xylocain inhibits the first and second phase of aggregation induced by unsaturated PAF. Hirudine shows no influence on the aggregation induced by unsaturated PAF.