✦ LIBER ✦

On the Synthesis of Bioisosters of O-Benzothiazolyloxybenzoic Acids and Evaluation as Aldose Reductase Inhibitors

✍ Scribed by Dietmar Rakowitz; Patric Muigg; Nicole Schröder; Barbara Matuszczak

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 115 KB
Volume: 338
Category: Article
ISSN: 0365-6233
DOI: 10.1002/ardp.200500119

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✦ Synopsis

Abstract

In continuation of our attempts to develop novel aldose reductase inhibitors (ARIs), a number of compounds characterized by bioisosteric replacement of pharmacophors were prepared. On the one hand, the acidic function was formally replaced by an oxime or a nitro group and on the other hand the lipophilic substituent was modified. The results of the biological evaluation of these derivatives enabled us to gain insight into structural features critical for the aldose reductase inhibition.

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