We wish to report the synthesis of the title compound (III), which is the first'reported 2.2 metacyclophane with substituents on the side chain3 CI and. by virtue of its conformation is also the first c3 2.2 metacyclophane in which H8 and H16 are magnetically non-equivalent.
On the stereoselective synthesis of 4,14-dimethyl[2.2]Metacyclophane
✍ Scribed by C. Glotzmann; E. Langer; H. Lihner; K. Schlögl
- Book ID
- 104213494
- Publisher
- Elsevier Science
- Year
- 1975
- Tongue
- French
- Weight
- 177 KB
- Volume
- 16
- Category
- Article
- ISSN
- 0040-4039
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## Abstract The synthesis of [4,5,6,8‐^2^H~4~][2.2]metacyclophane (8) was achieved starting with 2,4,5,6‐tetrafluoroisophthalic acid in eight steps in 2% total yield. ^1^H{^2^H} and ^13^C{^1^H} NMR spectra of 8 showed that the deuterium atoms were introduced at the desired positions.