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On the Regulation of the p53 Tumour Suppressor, and Its Role in the Cellular Response to DNA Damage

โœ Scribed by Lane, D. P.; Midgley, C. A.; Hupp, T. R.; Lu, X.; Vojtesek, B.; Picksley, S. M.


Book ID
120153144
Publisher
The Royal Society
Year
1995
Tongue
English
Weight
882 KB
Volume
347
Category
Article
ISSN
0080-4622

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Exposure of mammalian cells to genotoxic agents evokes a complex cellular response. An ordered series of molecular events is necessary to sense DNA damage, transduce the signal, and ultimately delay the cell cycle or trigger apoptosis. Recently, we have shown that BTG2/TIS21 gene expression was indu