On the Regioselectivity of Thioether Formation by Lacticin 481 Synthetase
β Scribed by Zhang, Xingang; Ni, Weijuan; van der Donk, Wilfred A.
- Book ID
- 126070348
- Publisher
- American Chemical Society
- Year
- 2007
- Tongue
- English
- Weight
- 107 KB
- Volume
- 9
- Category
- Article
- ISSN
- 1523-7060
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## Abstract **One enzyme, many substrates**. The substrate specificity of a lantibiotic biosynthetic enzyme, lacticin 481 synthetase, was probed by using synthetic prepeptides containing a variety of nonproteinogenic amino acids, including unnatural Ξ±βamino acids, Ξ²βamino acids, Dβamino acids, and
## Sir, Davis (1) concurs with the inter-relatedness of genetic code and amino acid biosynthesis evolution as proposed by the coevolution theory (CET) of the genetic code, (2,3) but argues against one of the postulates of CET, namely the formation of Asp-tRNA Asn and Glu-tRNA Gln during genetic co