Cover Picture: Investigation of the Substrate Specificity of Lacticin 481 Synthetase by Using Nonproteinogenic Amino Acids (ChemBioChem 5/2009)

Investigation of the Substrate Specifici

Investigation of the Substrate Specificity of Lacticin 481 Synthetase by Using Nonproteinogenic Amino Acids

✍ Matthew R. Levengood; Christopher C. Kerwood; Champak Chatterjee; Wilfred A. van 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 299 KB

## Abstract **One enzyme, many substrates**. The substrate specificity of a lantibiotic biosynthetic enzyme, lacticin 481 synthetase, was probed by using synthetic prepeptides containing a variety of nonproteinogenic amino acids, including unnatural α‐amino acids, β‐amino acids, D‐amino acids, and