Facile reaction of carboxylic acids with
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Jason G. Polisar; Ling Li; Jack R. Norton
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Article
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2011
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Elsevier Science
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French
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Isonitriles react with low concentrations of carboxylic acids in toluene at 110 ยฐC to give N-formylamides in yields generally above 70%. These concentrations can be obtained either by syringe pump addition of a toluene solution of the acid, or by using a suspension of the acid if it has limited solu