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On the reaction of carboxylic acids and isonitriles with conventional heating

โœ Scribed by Jason G. Polisar; Jack R. Norton


Book ID
119375790
Publisher
Elsevier Science
Year
2012
Tongue
French
Weight
295 KB
Volume
68
Category
Article
ISSN
0040-4020

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Facile reaction of carboxylic acids with
โœ Jason G. Polisar; Ling Li; Jack R. Norton ๐Ÿ“‚ Article ๐Ÿ“… 2011 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 281 KB

Isonitriles react with low concentrations of carboxylic acids in toluene at 110 ยฐC to give N-formylamides in yields generally above 70%. These concentrations can be obtained either by syringe pump addition of a toluene solution of the acid, or by using a suspension of the acid if it has limited solu