Facile reaction of carboxylic acids with isonitriles in toluene

✍ Scribed by Jason G. Polisar; Ling Li; Jack R. Norton

• Book ID: 104099120
• Publisher: Elsevier Science
• Year: 2011
• Tongue: French
• Weight: 281 KB
• Volume: 52
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/j.tetlet.2011.03.122

✦ Synopsis

Isonitriles react with low concentrations of carboxylic acids in toluene at 110 °C to give N-formylamides in yields generally above 70%. These concentrations can be obtained either by syringe pump addition of a toluene solution of the acid, or by using a suspension of the acid if it has limited solubility in toluene at room temperature.