On the prognostic value of systemic methotrexate clearance in childhood acute lymphocytic leukemia
✍ Scribed by Holger Seidel; Randi Nygaard; Peter J. Moe; Geir Jacobsen; Bo Lindqvist; Lars Slørdal
- Book ID
- 114119103
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 636 KB
- Volume
- 21
- Category
- Article
- ISSN
- 0145-2126
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
The prognostic value of systemic clearance of methotrexate (MTX) has been evaluated in 58 children with acute lymphoblastic leukemia, receiving altogether 380 MTX infusions in a dose range of 0.5 to 33.6 g/mZ. The linear regression analysis of dose-steady state concentration relationship revealed th
## Abstract ## Background Tromboembolic and hemorrhagic complications are significant causes of death in patients with malignancy. These are well‐known with the use of certain drugs. This study was planned to investigate whether there was any effect of high‐dose methotrexate on the hemostatic syst