๐”– Bobbio Scriptorium
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Prognostic importance of systemic clearance of methotrexate in childhood acute lymphoblastic leukemia

โœ Scribed by Joseph D. Borsi; Thomas Revesz; Dezso Schuler


Book ID
104683642
Publisher
Springer
Year
1987
Tongue
English
Weight
341 KB
Volume
19
Category
Article
ISSN
0344-5704

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The prognostic value of systemic clearance of methotrexate (MTX) has been evaluated in 58 children with acute lymphoblastic leukemia, receiving altogether 380 MTX infusions in a dose range of 0.5 to 33.6 g/mZ. The linear regression analysis of dose-steady state concentration relationship revealed th

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## BACKGROUND. Although it is widely accepted that failure to achieve complete remission (CR) portends a poor prognosis in childhood acute lymphoblastic leukemia (ALL), there is variability in the precise definition of induction failure and, to the authors' knowledge, few published data exist regar