The mechanism of the unique and specific association of a given amino acid to its t.-ltNA is investigated by theoretical methods. Several possible schemes are proposed t.o explain specificit.y. The physical forces which act wit.hin these mechanisms are illustrated by t,he computer simulation of prob
On the Optimization of the Physicochemical Distances between Amino Acids in the Evolution of the Genetic Code
β Scribed by Massimo Di Giulio; M.Rosaria Capobianco; Mario Medugno
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 490 KB
- Volume
- 168
- Category
- Article
- ISSN
- 0022-5193
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β¦ Synopsis
Using the simulated annealing technique we re-examine the role played by the minimization of the physicochemical distances between amino acids during the origin of the organization of the genetic code. The results are discussed in the context of the various hypotheses proposed to explain how amino acids were allocated in the genetic code.
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The synonym quotas within the genetic code for the 20 common amino acids are examined in relation to the ways in which these amino acids can be marshalled into different sets on the basis of shared physico-chemical properties. This reveals which shared properties are encouraged or discouraged during