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On the Dimerization of the Primitive tRNAs: Implications in the Origin of Genetic Code

✍ Scribed by JUAN A. MARTÍNEZ GIMÉNEZ; RAFAEL TABARÉS SEISDEDOS

Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
137 KB
Volume
217
Category
Article
ISSN
0022-5193

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✦ Synopsis

RNAs that catalyse their own aminoacylation have been recently selected in vitro. These findings support the notion that the primitive aminoacyl-tRNA synthetases may have been RNAs. In this paper, we propose a structural model for the first aminoacyl-tRNA synthetase consisting of an RNA complex formed between two primitive tRNA molecules through two intermolecular loop-strand interactions, and with implications in the origin of the genetic code.

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