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On the Classes of Aminoacyl-tRNA Synthetases and the Error Minimization in the Genetic Code

✍ Scribed by ANDRÉ R.O. CAVALCANTI; BENÍCIO DE BARROS NETO; RICARDO FERREIRA

Publisher: Elsevier Science
Year: 2000
Tongue: English
Weight: 181 KB
Volume: 204
Category: Article
ISSN: 0022-5193
DOI: 10.1006/jtbi.2000.1082

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✦ Synopsis

As a consequence of the existence of two classes of aminoacyl-tRNA synthetases (aaRSs), we de"ned two types of mutations: g (mutations that do not change the class of the involved amino acids) and u (those which change the class). We have found that the mean chemical distance resulting from g mutations is smaller than that corresponding to u mutations, indicating that g mutations are responsible for most of the known minimization of the genetic code. This supports models for the origin and evolution of the code, in which new amino acids were added after duplications or modi"cation of existing aaRSs.

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