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Use of the Kinetic Equilibrium between Aminoacyl-tRNA Formation and Hydrolysis in Inhibition Assays of Aminoacyl-tRNA Synthetase

✍ Scribed by Douglas B. Jordan; Lynn M. Abell; Michael A. Picollelli; David R. Senator; Jennifer L. Mason; M. John Rogers; Alan R. Rendina


Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
62 KB
Volume
298
Category
Article
ISSN
0003-2697

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On the Classes of Aminoacyl-tRNA Synthet
✍ ANDRΓ‰ R.O. CAVALCANTI; BENÍCIO DE BARROS NETO; RICARDO FERREIRA πŸ“‚ Article πŸ“… 2000 πŸ› Elsevier Science 🌐 English βš– 181 KB

As a consequence of the existence of two classes of aminoacyl-tRNA synthetases (aaRSs), we de"ned two types of mutations: g (mutations that do not change the class of the involved amino acids) and u (those which change the class). We have found that the mean chemical distance resulting from g mutati