## Abstract The genetic code is nearly universal, and the arrangement of the codons in the standard codon table is highly nonrandom. The three main concepts on the origin and evolution of the code are the stereochemical theory, according to which codon assignments are dictated by physicochemical af
Origin and evolution of the genetic code: The universal enigma
β Scribed by Eugene V. Koonin; Artem S. Novozhilov
- Publisher
- John Wiley and Sons
- Year
- 2009
- Tongue
- English
- Weight
- 107 KB
- Volume
- 61
- Category
- Article
- ISSN
- 1521-6543
- DOI
- 10.1002/iub.190
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β¦ Synopsis
Abstract
The expansion of the standard code according to the coevolution theory. Phase 1 amino acids are orange, and phase 2 amino acids are green. The numbers show the order of amino acid appearance in the code according to (99). The arrows define 13 precursorβproduct pairs of amino acids, their color defines the biosynthetic families of Glu (blue), Asp (darkβgreen), Phe (magenta), Ser (red), and Val (lightβgreen). See Origin and Evolution of the Genetic Code: The Universal Enigma by Koonin and Novozhilov, pp. 99β111.
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The main theories which have been suggested to explain the origin of genetic code organization are discussed. The coevolution theory, which considers the genetic code as a map of the biosynthetic relationships between amino acids, seems to be based on a mechanism that links it closely to certain sta
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