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Specificity in the genetic code: the role of nucleotide base–amino acid interaction

✍ Scribed by Marc S. Rendell; J. P. Harlos; Robert Rein

Publisher
Wiley (John Wiley & Sons)
Year
1971
Tongue
English
Weight
496 KB
Volume
10
Category
Article
ISSN
0006-3525

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✦ Synopsis

The mechanism of the unique and specific association of a given amino acid to its t.-ltNA is investigated by theoretical methods. Several possible schemes are proposed t.o explain specificit.y. The physical forces which act wit.hin these mechanisms are illustrated by t,he computer simulation of probable int,eract.ions between glycine and nricleot,ide bases and base pairs. It is demonstrated that, glycine has direct and selective affinities for the riucleot,ide bases and 1 hat. these interact,ioris are principally determined by t,he polar groups. Energies have been oitlculat,ed for the int,eractioti of glycine wit.h several base pairs. From these, t.he possibility t,hat. spec:ificit,y arises t,hrough direct, complexing of an amino acid with its ant,icodon is evaluated.

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