On the mechanism of the so-called uncoupling effect of medium- and short-chain fatty acids
✍ Scribed by Peter Schönfeld; Anna B. Wojtczak; Math J.H. Geelen; Wolfgang Kunz; Lech Wojtczak
- Book ID
- 115719267
- Publisher
- Elsevier Science
- Year
- 1988
- Tongue
- English
- Weight
- 638 KB
- Volume
- 936
- Category
- Article
- ISSN
- 0005-2728
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## Abstract Short chain fatty acids (SCFAs) are metabolic by products of anerobic bacteria fermentation. These fatty acids, despite being an important fuel for colonocytes, are also modulators of leukocyte function. The aim of this study was to evaluate the effects of SCFAs (acetate, propionate, an
## Short-chain (C,-C,) fatty acids account for 80%-70% of the anions in the colon. Acetate (C,) is nontoxic in contrast to C,,,,-C, fatty acids (propionate, butyrate, isobutyrate, valerate, and isovalerate). which induce coma in animals and may be important in the patho-gen& of hepatic coma in hum