On the mechanism of the reaction between ketones and trifluoromethanesulfonic anhydride. An improved and convenient method for the preparation of pyrimidines and condensed pyrimidines
โ Scribed by Garcia Martinez, A.; Herrera Fernandez, A.; Moreno Jimenez, F.; Garcia Fraile, A.; Subramanian, L. R.; Hanack, M.
- Book ID
- 121204616
- Publisher
- American Chemical Society
- Year
- 1992
- Tongue
- English
- Weight
- 469 KB
- Volume
- 57
- Category
- Article
- ISSN
- 0022-3263
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๐ SIMILAR VOLUMES
## Abstract A modification of the Pinner pyrimidine synthesis has been developed that utilizes trimethylsilyl amidines and results in greatly improved yield of highly substituted pyrimidines.
The environment-friendly three component condensation reactions of N,N%-dimethylbarbituric acid, 4-nitrobenzaldehyde and alkyl or aryl isocyanides to afford the corresponding furo[2,3-d]pyrimidine-2,4(1H,3H)-diones, in water, in high yields after several minutes are reported.
## Abstract For Abstract see ChemInform Abstract in Full Text.